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Literature summary for 3.4.23.39 extracted from

  • Asojo, O.A.; Afonina, E.; Gulnik, S.V.; Yu, B.; Erickson, J.W.; Randad, R.; Medjahed, D.; Silva, A.M.
    Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370 (2002), Acta Crystallogr. Sect. D, 58, 2001-2008.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of Met205Ser mutant enzyme in complex with the two inhibitors rs367 and rs370, crystals are grown at 293 K by vapor diffusion in hanging drops Plasmodium falciparum

Protein Variants

Protein Variants Comment Organism
M205S mutant enzyme with reduced chances of autolysis during purification Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
pepstatin A
-
 Plasmodium falciparum
rs367
-
 Plasmodium falciparum
rs370
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole food vacuole Plasmodium falciparum 5773
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Hemoglobin + H2O Plasmodium falciparum the enzyme initiates degradation of hemoglobin by cleavage at the alpha-chain between Phe33 and Leu34 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum P46925
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O the enzyme initiates degradation of hemoglobin by cleavage at the alpha-chain between Phe33 and Leu34 Plasmodium falciparum ?
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Plasmodium falciparum