Literature summary for 3.4.23.34 extracted from

Biyani, M.; Futakami, M.; Kitamura, K.; Kawakubo, T.; Suzuki, M.; Yamamoto, K.; Nishigaki, K.
In vitro selection of cathepsin E-activity-enhancing peptide aptamers at neutral pH (2011), Int. J. Pept., 2011, 834525.

Search for more literature for 3.4.23.34

Activating Compound

Activating Compound	Comment	Organism	Structure
IGCEERSFPNIIIIIG	up to 260% activation of cythepsin E, KD value about 300 nM. Treatment of HeLa cells with cathepsin E and peptide results in decrease in cell viability, with a 1.5- and 3-fold increase in the level of apoptosis in comparison to cells treated with cathepsin E alone	Rattus norvegicus
additional information	screening for cathepsin E-activity-enhancing peptides functioning in the physiological pH range as potential cancer therapeutic candidates	Rattus norvegicus
PGIKPPPCIIIIG	up to 180% activation of cythepsin E	Rattus norvegicus
SPIISHIVGCDPPSCG	up to 160% activation of cythepsin E	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Rattus norvegicus	-

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus

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Release 2023.1 (January 2023)