Cloned (Comment) | Organism |
---|---|
DNA sequence determination | Xenopus laevis |
location on chromosome 6 | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
crystal structure determination | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin | - |
Xenopus laevis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | in gastric juice | Sus scrofa | - |
- |
extracellular | in gastric juice | Xenopus laevis | - |
- |
extracellular | in gastric juice | Macaca fuscata | - |
- |
extracellular | in gastric juice, vaginal fluid, serum, and seminal plasma, no secretion in urine | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Macaca fuscata | - |
japanese macaque | - |
Sus scrofa | - |
- |
- |
Xenopus laevis | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the zymogen pepsinogen C is activated after secretion | Homo sapiens |
proteolytic modification | the zymogen pepsinogen C is activated after secretion | Sus scrofa |
proteolytic modification | the zymogen pepsinogen C is activated after secretion | Xenopus laevis |
proteolytic modification | the zymogen pepsinogen C is activated after secretion | Macaca fuscata |
Purification (Comment) | Organism |
---|---|
native enzyme from stomach | Sus scrofa |
native zymogen | Xenopus laevis |
native zymogen | Macaca fuscata |
native zymogen from stomach, prostate, breast cysts fluid, and seminal plasma, native mature enzyme from gastric fluid by anion exchange chromatography | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin | acid endopeptidase | Homo sapiens | |
more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin | acid endopeptidase | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
breast cyst | - |
Homo sapiens | - |
gastric juice | - |
Homo sapiens | - |
gastric juice | - |
Sus scrofa | - |
gastrointestinal tract | - |
Homo sapiens | - |
gastrointestinal tract | - |
Sus scrofa | - |
gastrointestinal tract | - |
Xenopus laevis | - |
gastrointestinal tract | - |
Macaca fuscata | - |
additional information | no expression in healthy breast tissue, reabsorption of zymogen from serum into kidney | Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
seminal plasma | - |
Homo sapiens | - |
seminal vesicle | synthesis | Homo sapiens | - |
serum | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
stomach | - |
Sus scrofa | - |
vaginal fluid | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | - |
Xenopus laevis | ? | - |
? | |
insulin B chain + H2O | cleavage of sites Leu15-Tyr16 and Tyr16-Leu17 | Macaca fuscata | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | secondary and tertiary structure determination | Homo sapiens |
More | structure determination | Macaca fuscata |
Synonyms | Comment | Organism |
---|---|---|
More | the enzyme belongs to the A1 peptidase family | Homo sapiens |
More | the enzyme belongs to the A1 peptidase family | Sus scrofa |
More | the enzyme belongs to the A1 peptidase family | Xenopus laevis |
More | the enzyme belongs to the A1 peptidase family | Macaca fuscata |
parapepsin II | - |
Sus scrofa |
pepsin C | - |
Homo sapiens |
pepsin C | - |
Sus scrofa |
pepsin C | - |
Xenopus laevis |
pepsin C | - |
Macaca fuscata |
pepsin II | - |
Homo sapiens |
seminal pepsin | - |
Homo sapiens |