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Literature summary for 3.4.23.3 extracted from

  • Tang, J.
    Gastricsin (2004), Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. ), 1, 38-43.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination Xenopus laevis
location on chromosome 6 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure determination Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
pepstatin
-
Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular in gastric juice Sus scrofa
-
-
extracellular in gastric juice Xenopus laevis
-
-
extracellular in gastric juice Macaca fuscata
-
-
extracellular in gastric juice, vaginal fluid, serum, and seminal plasma, no secretion in urine Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Macaca fuscata
-
japanese macaque
-
Sus scrofa
-
-
-
Xenopus laevis
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the zymogen pepsinogen C is activated after secretion Homo sapiens
proteolytic modification the zymogen pepsinogen C is activated after secretion Sus scrofa
proteolytic modification the zymogen pepsinogen C is activated after secretion Xenopus laevis
proteolytic modification the zymogen pepsinogen C is activated after secretion Macaca fuscata

Purification (Commentary)

Purification (Comment) Organism
native enzyme from stomach Sus scrofa
native zymogen Xenopus laevis
native zymogen Macaca fuscata
native zymogen from stomach, prostate, breast cysts fluid, and seminal plasma, native mature enzyme from gastric fluid by anion exchange chromatography Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin acid endopeptidase Homo sapiens
more restricted specificity than pepsin A, but shows preferential cleavage at Tyr-/- bonds. High activity on hemoglobin acid endopeptidase Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
breast cyst
-
Homo sapiens
-
gastric juice
-
Homo sapiens
-
gastric juice
-
Sus scrofa
-
gastrointestinal tract
-
Homo sapiens
-
gastrointestinal tract
-
Sus scrofa
-
gastrointestinal tract
-
Xenopus laevis
-
gastrointestinal tract
-
Macaca fuscata
-
additional information no expression in healthy breast tissue, reabsorption of zymogen from serum into kidney Homo sapiens
-
prostate gland
-
Homo sapiens
-
seminal plasma
-
Homo sapiens
-
seminal vesicle synthesis Homo sapiens
-
serum
-
Homo sapiens
-
stomach
-
Homo sapiens
-
stomach
-
Sus scrofa
-
vaginal fluid
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Hemoglobin + H2O
-
Xenopus laevis ?
-
?
insulin B chain + H2O cleavage of sites Leu15-Tyr16 and Tyr16-Leu17 Macaca fuscata ?
-
?

Subunits

Subunits Comment Organism
More secondary and tertiary structure determination Homo sapiens
More structure determination Macaca fuscata

Synonyms

Synonyms Comment Organism
More the enzyme belongs to the A1 peptidase family Homo sapiens
More the enzyme belongs to the A1 peptidase family Sus scrofa
More the enzyme belongs to the A1 peptidase family Xenopus laevis
More the enzyme belongs to the A1 peptidase family Macaca fuscata
parapepsin II
-
Sus scrofa
pepsin C
-
Homo sapiens
pepsin C
-
Sus scrofa
pepsin C
-
Xenopus laevis
pepsin C
-
Macaca fuscata
pepsin II
-
Homo sapiens
seminal pepsin
-
Homo sapiens