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Literature summary for 3.4.23.25 extracted from

  • Marques, M.; Mojzita, D.; Amorim, M.A.; Almeida, T.; Hohmann, S.; Moradas-Ferreira, P.; Costa, V.
    The Pep4p vacuolar proteinase contributes to the turnover of oxidized proteins but PEP4 overexpression is not sufficient to increase chronological lifespan in Saccharomyces cerevisiae (2006), Microbiology, 152, 3595-3605.
    View publication on PubMed
Search for more literature for 3.4.23.25

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole
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 Saccharomyces cerevisiae 5773
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae important for protein turnover after oxidative damage, supplies nitrogen under nutritional stress conditions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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 strains W303, W303 pep4D::HIS3, W303 pDP34, W303 pDP34-PEP4, and W303 p416ADHPEP4-GFP enzyme, increased enzyme expression induced by oxidative damage prevents the accumulation of oxidized proteins, disruption of PEP4 results in strongly decreased degradation of oxidized proteins
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Acid-denatured hemoglobin + H2O
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 Saccharomyces cerevisiae ? tyrosine-containing acid soluble peptides detected to measure enzyme activity ?
additional information important for protein turnover after oxidative damage, supplies nitrogen under nutritional stress conditions Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
PEP4 gene product
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 Saccharomyces cerevisiae
Pep4p
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 Saccharomyces cerevisiae
Pep4p vacuolar proteinase
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 Saccharomyces cerevisiae
Proteinase A
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 Saccharomyces cerevisiae