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Literature summary for 3.4.23.17 extracted from

  • Loh, Y.P.; Cawley, N.X.
    Processing enzymes of pepsin family: yeast aspartic protease 3 and pro-opiomelanocortin converting enzyme (1995), Methods Enzymol., 248, 136-146.
    View publication on PubMed
Search for more literature for 3.4.23.17

Inhibitors

Inhibitors Comment Organism Structure
Diazoacetylnorleucine methyl ester
-
 Bos taurus
leupeptin
-
 Bos taurus
leupeptin
-
 Rattus norvegicus
pepstatin A
-
 Bos taurus
pepstatin A
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane a soluble and a membrane component of the enzyme Rattus norvegicus 16020
-
membrane a soluble and a membrane component of the enzyme Bos taurus 16020
-
soluble a soluble and a membrane component of the enzyme Rattus norvegicus
-
-
soluble a soluble and a membrane component of the enzyme Bos taurus
-
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Bos taurus

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
hypophysis anterior Rattus norvegicus
-
hypophysis anterior Bos taurus
-
hypophysis intermediate Rattus norvegicus
-
hypophysis intermediate Bos taurus
-
hypophysis neural Rattus norvegicus
-
hypophysis neural Bos taurus
-

Storage Stability

Storage Stability Organism
-20°C, stable for 2-3 days Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NH2-terminal pro-opiomelanocortin1-77 + H2O O-linked glycosylation at Thr45 greatly inhibits the ability to cleave the Arg49-Lys50 bond Rattus norvegicus Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
 ?
NH2-terminal pro-opiomelanocortin1-77 + H2O O-linked glycosylation at Thr45 greatly inhibits the ability to cleave the Arg49-Lys50 bond Bos taurus Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
 ?
NH2-terminal pro-opiomelanocortin1-77 + H2O preferential cleavage between Arg49-Lys50 Bos taurus Lys-gamma3-melanotropin + NH2-terminal pro-opiomelanocortin1-49
-
 ?
Pro-opiomelanocortin + H2O
-
 Rattus norvegicus Adrenocorticotropin + beta-lipotropin
-
 ?
Pro-opiomelanocortin + H2O
-
 Bos taurus Adrenocorticotropin + beta-lipotropin
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4 5.5 mouse pro-opiomelanocortin Bos taurus