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Literature summary for 3.4.23.17 extracted from

  • Loh, Y.P.
    Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme (1986), J. Biol. Chem., 261, 11949-11955.
    View publication on PubMed
Search for more literature for 3.4.23.17

Inhibitors

Inhibitors Comment Organism Structure
Diazoacetylnorleucine methyl ester
-
 Bos taurus
leupeptin
-
 Bos taurus
pepstatin A
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0019
-
 beta-Lipotropin human substrate, cleavage at Lys37-Lys38 Bos taurus
0.0025
-
 beta-Lipotropin human substrate, cleavage at Lys57-Arg58 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hypophysis intermediate Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Human beta-lipotropin + H2O cleavage at two of the three pairs of basic residues of human beta-lipotropin, at Lys37-Lys38 and Lys57-Arg58, but not at Lys86-Lys87, the cleavage at Lys57-Arg58 occurs primarily between these basic residues Bos taurus More at enzyme concentration of 20 ng/0.1 ml: gamma-lipotropin + a beta-melanotropin linked to beta-endorphin intermediate + beta-endorpin, at enzyme concentration of 40 ng/0.1 ml: complete cleavage to yield beta-endorphin + beta-melanotrophin ?
Pro-opiomelanocortin + H2O
-
 Bos taurus Adrenocorticotropin + beta-lipotropin
-
 ?