Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aliskiren | direct renin inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | Homo sapiens | - |
angiotensin I + angiotensinogen propeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensinogen + H2O | - |
Homo sapiens | angiotensin I + angiotensinogen propeptide | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | renin-catalyzed conversion of angiotensinogen to angiotensin i is the rate-limiting step in the event cascade that activates the renin-angiotensin system. Renin directly increases the production of the fibrogenic cytokine transforming growth factor beta1 in the kidney | Homo sapiens |