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Literature summary for 3.4.23.15 extracted from

  • Hollenberg, N.K.
    Direct renin inhibition and the kidney (2010), Nat. Rev. Nephrol., 6, 49-55.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aliskiren direct renin inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensinogen + H2O Homo sapiens
-
angiotensin I + angiotensinogen propeptide
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O
-
Homo sapiens angiotensin I + angiotensinogen propeptide
-
?

General Information

General Information Comment Organism
physiological function renin-catalyzed conversion of angiotensinogen to angiotensin i is the rate-limiting step in the event cascade that activates the renin-angiotensin system. Renin directly increases the production of the fibrogenic cytokine transforming growth factor beta1 in the kidney Homo sapiens