Literature summary for 3.4.23.15 extracted from

Mueller, A.; Schweizer, J.; Kirch, W.; Schindler, C.; Schindler, C.
[Current status of antihypertensive drug treatment in primary care practice at launch of the new renin inhibitor aliskiren (RASANT)] (2010), Med. Klin., 105, 155-162.

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Application

Application	Comment	Organism
medicine	renin inhibition with aliskiren is useful for antihypertensive treatment in patients with severe arterial hypertension, in patients with an already long-lasting course of disease, and in the presence of comorbidities such as diabetes mellitus	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
aliskiren	direct renin inhibitor, aliskiren is useful for antihypertensive treatment in patients with severe arterial hypertension, in patients with an already long-lasting course of disease, and in the presence of comorbidities such as diabetes mellitus	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
angiotensinogen + H2O	Homo sapiens	-	angiotensin I + angiotensinogen propeptide	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
angiotensinogen + H2O	-	Homo sapiens	angiotensin I + angiotensinogen propeptide	-	?

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Release 2023.1 (January 2023)