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Literature summary for 3.4.23.15 extracted from

  • Sever, P.S.; Gradman, A.H.; Azizi, M.
    Managing cardiovascular and renal risk: the potential of direct renin inhibition (2009), J. Renin Angiotensin Aldosterone Syst., 10, 65-76.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
aliskiren direct renin inhibitor for the treatment of hypertension Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensinogen + H2O Homo sapiens renin catalyses the rate-limiting step in the system and has unique specificity for its substrate angiotensinogen angiotensin I + angiotensinogen propeptide
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
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juxtaglomerular cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensinogen + H2O renin catalyses the rate-limiting step in the system and has unique specificity for its substrate angiotensinogen Homo sapiens angiotensin I + angiotensinogen propeptide
-
?

Expression

Organism Comment Expression
Homo sapiens angiotensin II inhibits renin release from the juxtaglomerular cells in the kidney down

General Information

General Information Comment Organism
physiological function the renin-angiotensin-aldosterone system plays a key role in the regulation of blood volume, blood pressure, and cardiovascular and renal function Homo sapiens