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BRENDA support

Literature summary for 3.4.23.1 extracted from

  • Zavros, Y.; Waghray, M.; Tessier, A.; Bai, L.; Todisco, A.; L. Gumucio, D.; Samuelson, L.C.; Dlugosz, A.; Merchant, J.L.
    Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation (2007), J. Biol. Chem., 282, 33265-33274.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
stomach processing of sonic hedgehog in the normal stomach is hormonally regulated, acid-dependent, and mediated by the aspartic protease pepsin A. Parietal cell atrophy, a known preneoplastic lesion, correlates with loss of sonic hedgehog processing Mus musculus
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