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Literature summary for 3.4.23.1 extracted from
- Pepsin (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 3, 119-164.
No PubMed abstract available
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Sus scrofa |
- |
Scombridae gen. sp. |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amylopectin sulfate | - |
dogfish | |
| amylopectin sulfate | - |
Gallus gallus | |
| amylopectin sulfate | - |
salmon | |
| amylopectin sulfate | - |
Scombridae gen. sp. | |
| amylopectin sulfate | - |
shark | |
| amylopectin sulfate | - |
Sus scrofa | |
| Bis-(beta-chloroethyl)sulfide | - |
dogfish |  |
| Bis-(beta-chloroethyl)sulfide | - |
Gallus gallus | |
| Bis-(beta-chloroethyl)sulfide | - |
salmon | |
| Bis-(beta-chloroethyl)sulfide | - |
Scombridae gen. sp. | |
| Bis-(beta-chloroethyl)sulfide | - |
shark | |
| Bis-(beta-chloroethyl)sulfide | - |
Sus scrofa | |
| I2 | - |
dogfish | |
| I2 | - |
Gallus gallus | |
| I2 | - |
salmon | |
| I2 | - |
Scombridae gen. sp. | |
| I2 | - |
shark | |
| imidazole | hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | dogfish | |
| imidazole | hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Gallus gallus | |
| imidazole | hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | salmon | |
| imidazole | hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Scombridae gen. sp. | |
| imidazole | hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | shark | |
| imidazole | hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Sus scrofa | |
| KCN | similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | dogfish | |
| KCN | similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Gallus gallus | |
| KCN | similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | salmon | |
| KCN | similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Scombridae gen. sp. | |
| KCN | similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | shark | |
| KCN | similar effect as with imidazole, hemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Sus scrofa | |
| additional information | diazoketones; ketenes | dogfish | |
| additional information | diazoketones; ketenes | Gallus gallus | |
| additional information | diazoketones; ketenes | salmon | |
| additional information | diazoketones; ketenes | Scombridae gen. sp. | |
| additional information | diazoketones; ketenes | shark | |
| additional information | diazoketones; ketenes | Sus scrofa | |
| N-bromosuccinimide | - |
dogfish | |
| N-bromosuccinimide | - |
Gallus gallus | |
| N-bromosuccinimide | - |
salmon | |
| N-bromosuccinimide | - |
Scombridae gen. sp. | |
| N-bromosuccinimide | - |
shark | |
| N-bromosuccinimide | - |
Sus scrofa | |
| p-bromophenylacyl bromide | - |
dogfish | |
| p-bromophenylacyl bromide | - |
Gallus gallus | |
| p-bromophenylacyl bromide | - |
salmon | |
| p-bromophenylacyl bromide | - |
Scombridae gen. sp. | |
| p-bromophenylacyl bromide | - |
shark | |
| p-bromophenylacyl bromide | - |
Sus scrofa | |
| peptides | 29 amino acid peptide liberated in activation of pepsinogen | dogfish | |
| peptides | 29 amino acid peptide liberated in activation of pepsinogen | Gallus gallus | |
| peptides | 29 amino acid peptide liberated in activation of pepsinogen | salmon | |
| peptides | 29 amino acid peptide liberated in activation of pepsinogen | Scombridae gen. sp. | |
| peptides | 29 amino acid peptide liberated in activation of pepsinogen | shark | |
| peptides | 29 amino acid peptide liberated in activation of pepsinogen | Sus scrofa | |
| poly-L-lysine | - |
dogfish | |
| poly-L-lysine | - |
Gallus gallus | |
| poly-L-lysine | - |
salmon | |
| poly-L-lysine | - |
Scombridae gen. sp. | |
| poly-L-lysine | - |
shark | |
| poly-L-lysine | - |
Sus scrofa | |
| Tetranitromethane | similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | dogfish | |
| Tetranitromethane | similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Gallus gallus | |
| Tetranitromethane | similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | salmon | |
| Tetranitromethane | similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Scombridae gen. sp. | |
| Tetranitromethane | similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | shark | |
| Tetranitromethane | similar effect as with imidazole, haemoglobin hydrolysis inhibited, cleavage of small synthetic peptide and ester substrates enhanced | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Gallus gallus | |
| additional information | - |
additional information | - |
Sus scrofa | |
| additional information | - |
additional information | - |
salmon | |
| additional information | - |
additional information | - |
shark | |
| additional information | - |
additional information | - |
Scombridae gen. sp. | |
| additional information | - |
additional information | - |
dogfish |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
| additional information | - |
- |
Sus scrofa |
| additional information | - |
- |
salmon |
| additional information | - |
- |
shark |
| additional information | - |
- |
Scombridae gen. sp. |
| additional information | - |
- |
dogfish |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proteins + H2O | Gallus gallus | enzyme formed from pepsinogen A, agent of gastric digestion in mammals and birds | ? | - |
? | |
| Proteins + H2O | Gallus gallus | preferential cleavage: Phe-, Leu- | ? | - |
? | |
| Proteins + H2O | Sus scrofa | preferential cleavage: Phe-, Leu- | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| dogfish | - |
- |
- |
| Gallus gallus | - |
- |
- |
| salmon | - |
- |
- |
| Scombridae gen. sp. | - |
- |
- |
| shark | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric mucosa | - |
Sus scrofa | - |
| gastric mucosa | - |
Scombridae gen. sp. | - |
| gastric mucosa | - |
dogfish | - |
| stomach | - |
Gallus gallus | - |
| stomach | - |
salmon | - |
| stomach | - |
shark | - |
| stomach | - |
Scombridae gen. sp. | - |
| stomach | - |
dogfish | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O | - |
Gallus gallus | benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester | - |
? | |
| benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O | - |
Sus scrofa | benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester | - |
? | |
| benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O | - |
salmon | benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester | - |
? | |
| benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O | - |
shark | benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester | - |
? | |
| benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O | - |
Scombridae gen. sp. | benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester | - |
? | |
| benzyloxycarbonyl-His-Phe(NO2)-beta-phenyl-L-lactyl-O-methyl ester + H2O | - |
dogfish | benzyloxycarbonyl-His-Phe(NO2) + phenyl-L-lactyl-O-methyl ester | - |
? | |
| Hemoglobin + H2O | - |
Gallus gallus | ? | - |
? | |
| Hemoglobin + H2O | - |
Sus scrofa | ? | - |
? | |
| Hemoglobin + H2O | - |
Scombridae gen. sp. | ? | - |
? | |
| Hemoglobin + H2O | - |
dogfish | ? | - |
? | |
| additional information | transpeptidation reactions | Gallus gallus | ? | - |
? | |
| additional information | transpeptidation reactions | Sus scrofa | ? | - |
? | |
| additional information | transpeptidation reactions | salmon | ? | - |
? | |
| additional information | transpeptidation reactions | shark | ? | - |
? | |
| additional information | transpeptidation reactions | Scombridae gen. sp. | ? | - |
? | |
| additional information | transpeptidation reactions | dogfish | ? | - |
? | |
| additional information | absolute requirement for L-enantiomer in both the X and Y position of substrate | Gallus gallus | ? | - |
? | |
| additional information | absolute requirement for L-enantiomer in both the X and Y position of substrate | Sus scrofa | ? | - |
? | |
| additional information | absolute requirement for L-enantiomer in both the X and Y position of substrate | salmon | ? | - |
? | |
| additional information | absolute requirement for L-enantiomer in both the X and Y position of substrate | shark | ? | - |
? | |
| additional information | absolute requirement for L-enantiomer in both the X and Y position of substrate | Scombridae gen. sp. | ? | - |
? | |
| additional information | absolute requirement for L-enantiomer in both the X and Y position of substrate | dogfish | ? | - |
? | |
| additional information | condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products | Gallus gallus | ? | - |
? | |
| additional information | condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products | Sus scrofa | ? | - |
? | |
| additional information | condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products | salmon | ? | - |
? | |
| additional information | condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products | shark | ? | - |
? | |
| additional information | condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products | Scombridae gen. sp. | ? | - |
? | |
| additional information | condensation reaction: pH 4, high substrate concentrations, oligopeptides converted to polymeric products | dogfish | ? | - |
? | |
| additional information | side chain specificity | Gallus gallus | ? | - |
? | |
| additional information | side chain specificity | Sus scrofa | ? | - |
? | |
| additional information | side chain specificity | salmon | ? | - |
? | |
| additional information | side chain specificity | shark | ? | - |
? | |
| additional information | side chain specificity | Scombridae gen. sp. | ? | - |
? | |
| additional information | side chain specificity | dogfish | ? | - |
? | |
| additional information | organic sulfites | Gallus gallus | ? | - |
? | |
| additional information | organic sulfites | Sus scrofa | ? | - |
? | |
| additional information | organic sulfites | salmon | ? | - |
? | |
| additional information | organic sulfites | shark | ? | - |
? | |
| additional information | organic sulfites | Scombridae gen. sp. | ? | - |
? | |
| additional information | organic sulfites | dogfish | ? | - |
? | |
| Proteins + H2O | enzyme formed from pepsinogen A, agent of gastric digestion in mammals and birds | Gallus gallus | ? | - |
? | |
| Proteins + H2O | preferential cleavage: Phe-, Leu- | Gallus gallus | ? | - |
? | |
| Proteins + H2O | preferential cleavage: Phe-, Leu- | Sus scrofa | ? | - |
? | |
| serum albumin + H2O | - |
dogfish | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Gallus gallus |
| 37 | - |
assay at | Sus scrofa |
| 37 | - |
assay at | salmon |
| 37 | - |
assay at | shark |
| 37 | - |
assay at | Scombridae gen. sp. |
| 37 | - |
assay at | dogfish |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Sus scrofa | |
| additional information | - |
additional information | - |
salmon | |
| additional information | - |
additional information | - |
shark | |
| additional information | - |
additional information | - |
Scombridae gen. sp. | |
| additional information | - |
additional information | - |
dogfish |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
| additional information | - |
- |
Sus scrofa |
| additional information | - |
- |
salmon |
| additional information | - |
- |
shark |
| additional information | - |
- |
Scombridae gen. sp. |
| additional information | - |
- |
dogfish |
| 2 | - |
- |
Gallus gallus |
| 2 | - |
- |
salmon |
| 2 | - |
- |
shark |
| 2 | - |
- |
Scombridae gen. sp. |
| 2 | - |
- |
dogfish |
| 3.5 | - |
- |
Gallus gallus |
| 3.5 | - |
- |
salmon |
| 3.5 | - |
- |
shark |
| 3.5 | - |
- |
Scombridae gen. sp. |
| 3.5 | - |
- |
dogfish |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
| additional information | - |
- |
Sus scrofa |
| additional information | - |
- |
salmon |
| additional information | - |
- |
shark |
| additional information | - |
- |
Scombridae gen. sp. |
| additional information | - |
- |
dogfish |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
autolytic degradation in acid solution | Sus scrofa |
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