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Literature summary for 3.4.22.B75 extracted from

  • Bawa-Khalfe, T.; Lu, L.S.; Zuo, Y.; Huang, C.; Dere, R.; Lin, F.M.; Yeh, E.T.
    Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition (2012), Proc. Natl. Acad. Sci. USA, 109, 17466-17471.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B75

Localization

Localization Comment Organism GeneOntology No. Textmining
chromatin
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 Homo sapiens 785
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nucleus
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 Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SUMO2/3ylated HP1alpha + H2O Homo sapiens HP1alpha localizes at the pericentric heterochromatin, importance of SUMOylation in directing HP1alpha’s subnuclear localization, SUMO deconjugation by enzyme SENP7 HP1alpha + SUMO3 + SUMO2
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 two splicing variants, a short SENP7 splice variant SENP7S and a long transcript SENP7L
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Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
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 Homo sapiens
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breast epithelial cell two splicing variants, a short SENP7 splice variant SENP7S and a long transcript SENP7L Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information long enzyme variant SENP7L, but not short enzyme variant SENP7S, binds HP1alpha. This interaction does not require catalytic activity: both the active wild-type SENP7L and the catalytically inactive mutant (SENP7Lm) bind endogenous HP1alpha efficiently Homo sapiens ?
-
 ?
SUMO2/3ylated HP1alpha + H2O HP1alpha localizes at the pericentric heterochromatin, importance of SUMOylation in directing HP1alpha’s subnuclear localization, SUMO deconjugation by enzyme SENP7 Homo sapiens HP1alpha + SUMO3 + SUMO2
-
 ?
SUMO2/3ylated HP1alpha + H2O SUMO deconjugation by enzyme SENP7 Homo sapiens HP1alpha + SUMO3 + SUMO2
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 ?

Synonyms

Synonyms Comment Organism
SENP7
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 Homo sapiens
sentrin/small ubiquitin-like modifier-specific protease 7
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 Homo sapiens
SUMO-specific protease 7
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 Homo sapiens

General Information

General Information Comment Organism
malfunction loss of SENP7LHP1alpha interaction causes HP1alpha hyperSUMOylation, an enrichment of HP1alpha at E2F-responsive and mesenchymal gene promoters, silences transcription of these genes, and elicits cellular senescence. Reducing all catalytically active SENP7 isoforms prompts a reduction in GILM2 cells' invasiveness. Lower mRNA of E2F-responsive genes and vimentin in tumor mass from GI101a-shSENP7 and GILM2-shSENP7 than their respective shNT control xenografts Homo sapiens
physiological function induction of SENP7L long variant maintains hypoSUMOylated HP1alpha, which relieves HP1alpha-mediated repression of proliferation promoting E2F-responsive genes as well as mesenchymal genes Homo sapiens