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Literature summary for 3.4.22.B75 extracted from

  • Maison, C.; Romeo, K.; Bailly, D.; Dubarry, M.; Quivy, J.P.; Almouzni, G.
    The SUMO protease SENP7 is a critical component to ensure HP1 enrichment at pericentric heterochromatin (2012), Nat. Struct. Mol. Biol., 19, 458-460.
    View publication on PubMed
Search for more literature for 3.4.22.B75

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of GFP-tagged wild-type and mutant enzyme SENP7 Mus musculus

Protein Variants

Protein Variants Comment Organism
C979S site-directed mutagenesis Mus musculus
additional information Depletion of SENP7 from NIH-3T3 cells by transfecting a plasmid encoding both a microRNA to downregulate SENP7 (miSENP7) and a GFP mRNA to enable identification of the transfected cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SUMOylated HP1alpha + H2O Mus musculus SUMO deconjugation by enzyme SENP7 HP1alpha + SUMO
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SUMOylated HP1alpha + H2O SUMO deconjugation by enzyme SENP7 Mus musculus HP1alpha + SUMO
-
 ?

Synonyms

Synonyms Comment Organism
SUMO protease SENP7
-
 Mus musculus
SUMO-specific protease SENP7
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme SENP7 depleted cells show reduced localization of HP1alpha at pericentric heterochromatin domains, while trimethylated histone H3 Lys9 (H3K9me3) remains present at these domains Mus musculus
physiological function the SUMO-specific protease SENP7 in mouse is a maintenance factor for HP1alpha accumulation at pericentric heterochromatin. Enzyme SENP7 interacts directly with HP1alpha, localizes at HP1-enriched pericentric domain,s and can deconjugate SUMOylated HP1alpha in vivo. SUMOylation promotes targeting of HP1alpha to pericentric heterochromatin. DeSUMOylation event enables HP1alpha retention at these domains Mus musculus