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Literature summary for 3.4.22.B75 extracted from

  • Garvin, A.J.; Densham, R.M.; Blair-Reid, S.A.; Pratt, K.M.; Stone, H.R.; Weekes, D.; Lawrence, K.J.; Morris, J.R.
    The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair (2013), EMBO Rep., 14, 975-983.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B75

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of N-terminally FLAG-tagged wild-type and mutant enzymes in HEK-293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
C992A site-directed mutagenesis, inactive catalytic mutant Homo sapiens
additional information enzyme knockout by siRNA in HeLa cells, complementation of knockdown with siRNA-resistant Flag-SENP7 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1 ?
-
 ?
SUMOylated KRAB-associated protein 1 + H2O Homo sapiens enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1 KRAB-associated protein 1 + SUMO 2 + SUMO3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme SENP7 interacts with the chromatin repressive KRAB-associated protein 1 through heterochromatin protein 1 alpha, HP1alapha. Enzyme SENP7 contains a conserved HP1-box, PxVxL, required for interaction with HP1 Homo sapiens ?
-
 ?
polySUMO2 KRAB-associated protein 1 + H2O enzyme SENP7 promotes the removal of SUMO2 from KRAB-associated protein 1 Homo sapiens KRAB-associated protein 1 + SUMO 2 + SUMO3
-
 ?
SUMOylated KRAB-associated protein 1 + H2O enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1 Homo sapiens KRAB-associated protein 1 + SUMO 2 + SUMO3
-
 ?

Synonyms

Synonyms Comment Organism
SENP7
-
 Homo sapiens
SUMO/sentrin/Smt3-specific peptidase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction homologous recombination is affected in SENP7 knockout cells Homo sapiens
metabolism DNA damage-associated remodelling requires SENP7, overview Homo sapiens
physiological function enzyme SENP7 promotes the removal of SUMO2/3 from KRAB-associated protein 1 and regulates the interaction of the chromatin remodeler CHD3 with chromatin. In the presence of CHD3, SENP7 is required for chromatin relaxation in response to DNA damage, for homologous recombination repair and for cellular resistance to DNA-damaging agents. DeSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair. Enzyme SENP7 is required for localized euchromatin relaxation Homo sapiens