Cloned (Comment) | Organism |
---|---|
transgenic overexpression of SENP5 in murine cardiomyocytes, overexpression of SENP5 leads to cardiac dysfunction, accompanied by decreased cardiomyocyte proliferation and elevated apoptosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
SUMOylated dynamin related protein + H2O | Homo sapiens | - |
dynamin related protein + SUMO | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | significant increase in the level of enzyme SENP5 in human idiopathic failing hearts | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
SUMOylated dynamin related protein + H2O | - |
Homo sapiens | dynamin related protein + SUMO | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP5 | - |
Homo sapiens |
SUMO isopeptidase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | SENP5 enzyme overexpression leads to cardiac dysfunction, accompanied by decreased cardiomyocyte proliferation and elevated apoptosis, overview. Transgenic SENP5-hearts, that are larger than wild-type, unveil a decrease in SUMO attachment to dynamin related protein (Drp1), a factor critical for mitochondrial fission, phenotype, overview | Homo sapiens |
metabolism | SUMO conjugation is a dynamic posttranslational modification that can be readily reversed by the activity of sentrin-specific proteases (SENPs). Elevated expression of SENP5 in the failing human hearts, development of cardiomyopathy, overview | Homo sapiens |
physiological function | SUMO isopeptidase SENP5 induces apoptosis and cardiomyopathy, which represents a major health issue and is a leading cause of heart failure. Significant increase in the level of enzyme SEN,P5 in human idiopathic failing hearts | Homo sapiens |