Literature summary for 3.4.22.B71 extracted from

Chang, C.C.; Huang, Y.S.; Lin, Y.M.; Lin, C.J.; Jeng, J.C.; Liu, S.M.; Ho, T.L.; Chang, R.T.; Changou, C.A.; Ho, C.C.; Shih, H.M.
The role of sentrin-specific protease 2 substrate recognition in TGF-beta-induced tumorigenesis (2018), Sci. Rep., 8, 9786 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HC62	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated Smad4 + H2O	Smad4 forms complexes with receptor-phosphorylated Smads, and transduces transforming growth factor-beta signals into the nuclei	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	SENP2 interacts with Smad4 through SENP2 residue 363-400. The same segment is also important for desumoylation of Smad4, and able to relieve sumoylation-mediated TGF-beta repression. The SENP2363-400 segment is critical for TGF-beta-induced cell migration, which is correlated with SENP2363-400 deletion mutant that fails to increase matrix metalloproteinase (MMP)-9 and epithelial-to-mesenchymal transition marker gene expression. The interaction and desumoylation between SENP2 and Smad4 promote cell migration in triple-negative breast cancer cells	Homo sapiens

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Release 2023.1 (January 2023)