Literature summary for 3.4.22.B71 extracted from

Maruyama, E.O.; Lin, H.; Chiu, S.Y.; Yu, H.M.; Porter, G.A.; Hsu, W.
Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development (2016), Sci. Rep., 6, 20999 .

Search for more literature for 3.4.22.B71

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91ZX6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated Mdm2 + H2O	Mdm2 controls p53 activities critical for G-S transition of mitotic division and endoreduplication in trophoblast proliferation and differentiation	Mus musculus	?	-	?

General Information

General Information	Comment	Organism
physiological function	development of a mouse strain permitting conditional inactivation of SENP2. Mice homozygous for germline deletion of the conditional allele exhibit trophoblast defects and embryonic abnormalities resembling the global SENP2 knockout. SENP2 is dispensable in embryogenesis. Placental expression of SENP2 is necessary and sufficient for embryonic heart and brain development. SENP2-dependent SUMO modification is required in development of all major trophoblast lineages. SENP2 regulates sumoylation of Mdm2 which controls p53 activities critical for G-S transition of mitotic division and endoreduplication in trophoblast proliferation and differentiation, respectively	Mus musculus

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Release 2023.1 (January 2023)