Literature summary for 3.4.22.B71 extracted from

Tan, M.; Gong, H.; Wang, J.; Tao, L.; Xu, D.; Bao, E.; Liu, Z.; Qiu, J.
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1 (2015), Sci. Rep., 5, 13996 .

Search for more literature for 3.4.22.B71

Application

Application	Comment	Organism
medicine	in bladder cancer cells, SENP2 inhibits MMP13 expression through deSUMOylation of TBL1/TBLR1, which inhibits nuclear translocation of beta-catenin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HC62	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
T-24 cell	bladder cancer cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated TBL1/TBLR1 + H2O	i.e. transcriptional cofactor transducin beta-like	Homo sapiens	?	-	?

General Information

General Information	Comment	Organism
physiological function	SENP2 inhibits nuclear translocation of beta-catenin, which targets the promotor of MMP13 to activate MMP13 to enhance bladder cancer cell metastasis	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)