Literature summary for 3.4.22.B71 extracted from

Zheng, Q.; Cao, Y.; Chen, Y.; Wang, J.; Fan, Q.; Huang, X.; Wang, Y.; Wang, T.; Wang, X.; Ma, J.; Cheng, J.
Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 (2018), J. Mol. Cell Biol., 10, 258-266 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91ZX6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipocyte	-	Mus musculus	-
adipose tissue	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated Setdb1 + H2O	i.e. SET domain bifurcated 1, a histone methyltransferase for H3K9 trimethylation	Mus musculus	?	-	?

General Information

General Information	Comment	Organism
physiological function	adipocyte Senp2 deficiency results in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feeding. SET domain bifurcated 1 (Setdb1) is a SUMOylated protein and SUMOylation promotes Setdb1 occupancy on the promoter locus of Pparg and Cebpa genes to suppress their expressions via histone H3K9me3. Senp2 can suppress Setdb1 function by deSUMOylation. In adipocyte Senp2-deficiency mice, accumulation of the SUMOylated Setdb1 suppresses the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes	Mus musculus

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Release 2023.1 (January 2023)