Literature summary for 3.4.22.B71 extracted from

Pei, H.; Chen, L.; Liao, Q.M.; Wang, K.J.; Chen, S.G.; Liu, Z.J.; Zhang, Z.C.
SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation (2018), Exp. Ther. Med., 16, 5359-5365 .

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Application

Application	Comment	Organism
medicine	SENP2 expression is significantly downregulated in clinical osteosarcoma tissues compared with adjacent normal samples. Ectopic expression of SENP2 results in the suppression of proliferation, migration and invasion in osteosarcoma cells, whereas SENP2 knockdown has the opposite effect. SENP2 is associated with the proteaxadsome-dependent ubiquitination and degradation of SRY-box-9 (SOX9). SOX9 silencing impairs SENP2-depletion-induced accelerated cell growth and migration	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HOS cell	-	Homo sapiens	-
MG-63 cell	-	Homo sapiens	-
osteosarcoma cell	-	Homo sapiens	-
SAOS-2 cell	-	Homo sapiens	-
U2-OS cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	ectopic expression of SENP2 results in the suppression of proliferation, migration and invasion in osteosarcoma cells, whereas SENP2 knockdown has the opposite effect	Homo sapiens

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Release 2023.1 (January 2023)