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Literature summary for 3.4.22.B71 extracted from

  • Tang, S.; Huang, G.; Tong, X.; Xu, L.; Cai, R.; Li, J.; Zhou, X.; Song, S.; Huang, C.; Cheng, J.
    Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism (2013), PLoS ONE, 8, e63965.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B71

Protein Variants

Protein Variants Comment Organism
additional information enzyme knockout by RNA interference in MCF-7 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell weak expression, benign breast adenofibroma cell and malignant breast cancer tissue Homo sapiens
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MCF-7 cell
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 Homo sapiens
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MEF cell
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 Mus musculus
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Synonyms

Synonyms Comment Organism
SENP2
-
 Mus musculus
SENP2
-
 Homo sapiens
SUMO-specific protease 2
-
 Mus musculus
SUMO-specific protease 2
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 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme SENP2 knockout MEF cells show increased glucose uptake and lactate production along with decreased ATP levels. SENP2 knockout embryonic fibroblasts exhibit increased levels of phosphorylated AKT. Inhibiting AKT phosphorylation by LY294002 rescues the phenotype induced by SENP2 deficiency in embryonic fibroblasts. Knockout of SENP2 leads to increased aerobic glycolysis in MEF cells Mus musculus
malfunction overexpression of enzyme SENP2 reduces the glucose uptake and lactate production, increasing the cellular ATP levels in MCF-7 cells. The MCF-7 cells overexpressing enzyme SENP2 exhibit decreased expression levels of key glycolytic enzymes and an increased rate of glucose oxidation compared with control MCF-7 cells, indicating inhibited glycolysis but enhanced oxidative mitochondrial respiration. The cells have a reduced amount of phosphorylated AKT Homo sapiens
metabolism SENP2 overexpression in MCF-7 cells reprograms glucose metabolism Homo sapiens
physiological function enzyme SENP2 represses glycolysis and shifts glucose metabolic strategy, in part through inhibition of AKT phosphorylation, function of SENP2 in regulating glucose metabolism, overview Mus musculus
physiological function enzyme SENP2 represses glycolysis and shifts glucose metabolic strategy, in part through inhibition of AKT phosphorylation, function of SENP2 in regulating glucose metabolism, overview Homo sapiens