Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nuclear pore complex | - |
Homo sapiens | - |
- |
nuclear envelope | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
SENP2 | - |
Homo sapiens |
sentrin/SUMO-specific protease 2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | differential localization of nucleoporins upon codepletion of SENP1 and SENP2 in HeLa cells, immunohistochemic analysis, overview | Homo sapiens |
physiological function | SENP2, as well as SENP1, regulates the proper localization of nucleoporins, overview. The enzyme interacts with the nucleoporin Nup153 via a dual interface that includes a bridging interaction with the soluble transport receptor importin beta and a SUMO-mediated mechanism, and also with Nup358 and members of the Nup107-160 complex at distinct regions of SENP2 that can independently direct SENP2 to the nuclear rim. SENP1 and SENP2 are not required for localization of the transmembrane proteins nucleoporin POM121 and inner nuclear envelope protein Sun1 or expansion of the interphase nuclear envelope | Homo sapiens |