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Literature summary for 3.4.22.B71 extracted from

  • Qi, Y.; Zuo, Y.; Yeh, E.T.; Cheng, J.
    An essential role of small ubiquitin-like modifier (SUMO)-specific protease 2 in myostatin expression and myogenesis (2014), J. Biol. Chem., 289, 3288-3293.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B71

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SUMOylated myocyte-specific enhancer factor-2A + H2O Mus musculus deSUMOylation by enzyme SENP2 deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?
SUMOylated myocyte-specific enhancer factor-2A + H2O Mus musculus C57BL/6 deSUMOylation by enzyme SENP2 deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Mus musculus
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embryo
-
 Mus musculus
-
heart
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-
additional information correlation of Senp2 and myostatin expression in cachexia Mus musculus
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satellite stem cell isolated from skeletal muscle Mus musculus
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skeletal muscle
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SUMOylated myocyte-specific enhancer factor-2A + H2O deSUMOylation by enzyme SENP2 Mus musculus deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?
SUMOylated myocyte-specific enhancer factor-2A + H2O deSUMOylation by enzyme SENP2 Mus musculus C57BL/6 deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
 ?

Synonyms

Synonyms Comment Organism
small ubiquitin-like modifier-specific protease 2
-
 Mus musculus
SUMO-specific protease 2
-
 Mus musculus

General Information

General Information Comment Organism
additional information Correlation of Senp2 and myostatin expression in cachexia Mus musculus
physiological function the broad deSUMOylation activity of the enzyme in vitro is essential for embryonic heart development, essential role of small ubiquitin-like modifier-specific protease 2 in myostatin expression and myogenesis, overview. Enzyme SENP2 regulates the transcription of myostatin mainly through deSUMOylation of MEF2A. MEF2A mediates SENP2 activity on the myostatin promoter involving the MEF2 binding site. Enzyme SENP2 inhibits skeletal myogenesis Mus musculus