Literature summary for 3.4.22.B71 extracted from

Koo, Y.D.; Choi, J.W.; Kim, M.; Chae, S.; Ahn, B.Y.; Kim, M.; Oh, B.C.; Hwang, D.; Seol, J.H.; Kim, Y.B.; Park, Y.J.; Chung, S.S.; Park, K.S.
SUMO-specific protease 2 (SENP2) is an important regulator of fatty acid metabolism in skeletal muscle (2015), Diabetes, 64, 2420-2431.

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Application

Application	Comment	Organism
medicine	muscle enzyme SENP2 can be a therapeutic target for the treatment of obesity-linked metabolic disorders	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C2C12 cell	-	Mus musculus	-
myotube	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
SENP2	-	Mus musculus
small ubiquitin-like modifier-specific protease	-	Mus musculus
SUMO-specific protease	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	in C2C12 myotubes, treatment with saturated fatty acids, like palmitate, leads to nuclear factor-kappaB-mediated increase in the expression of SENP2	up

General Information

General Information	Comment	Organism
physiological function	nuclear factor-kappaB-mediated increase in the expression of SENP2 promotes the recruitment of peroxisome proliferator-activated receptors PPARdelta and PPARgamma, through deSUMOylation of PPARs, to the promoters of the genes involved in fatty acid oxidation, such as carnitine-palmitoyl transferase-1 and long-chain acyl-CoA synthetase 1. Enzyme overexpression substantially increases fatty acid oxidation in C2C12 myotubes	Mus musculus

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Release 2023.1 (January 2023)