Literature summary for 3.4.22.B71 extracted from

Tan, M.Y.; Mu, X.Y.; Liu, B.; Wang, Y.; Bao, E.D.; Qiu, J.X.; Fan, Y.
SUMO-specific protease 2 suppresses cell migration and invasion through inhibiting the expression of MMP13 in bladder cancer cells (2013), Cell. Physiol. Biochem., 32, 542-548.

Search for more literature for 3.4.22.B71

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant expression of FLAG-tagged enzyme in HEK-293T cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme knockout by siRNA against SENP2	Homo sapiens
R576L/K577M	the catalytically inactive enzyme mutant SENP2Cat cannot regulate MMP13	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bladder cancer cell	the enzyme is down-regulated in bladder cancer samples	Homo sapiens	-
EJ cell	-	Homo sapiens	-
T-24 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
SENP2	-	Homo sapiens
SUMO-specific protease 2	-	Homo sapiens

General Information

General Information	Comment	Organism
evolution	SUMO-specific protease 2 (SENP2) is a de-SUMOylation protease family member	Homo sapiens
malfunction	silencing the expression of enzyme SENP2 significantly induces the expression of MMP13 , forced MMP13 expression is sufficient to restore cell invasion in SENP2 overexpressed T24 bladder cancer cells	Homo sapiens
physiological function	SUMO-specific protease 2 suppresses cell migration and invasion through selectively inhibiting the expression of MMP13 in bladder cancer cells, the enzyme has an indispensable role in the regulation of NF-kappaB transcriptional activation and Wnt signaling. The enzyme inhibits bladder cancer cells migration and invasion in vitro	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)