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Literature summary for 3.4.22.B71 extracted from

  • Reverter, D.; Lima, C.D.
    A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex (2004), Structure, 12, 1519-1531.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
Senp2 crystallization is performed at 4°C using sitting and hanging drop vapor diffusion methods. X-ray structures of Senp2 catalytic protease domain and of a covalent thiohemiacetal transition-state complex obtained between the Senp2 catalytic domain and SUMO-1 reveales details of the respective protease and substrate surfaces utilized in interactions between these two proteins. Comparative biochemical and structural analysis between Senp2 and the yeast SUMO protease Ulp1 reveales differential abilities to process SUMO-1, SUMO-2, and SUMO-3 in maturation and deconjugation reactions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HC62
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O
-
Homo sapiens SUMO-1 + Ran GTPase-activating protein 1
-
?
(SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O
-
Homo sapiens SUMO-2 + Ran GTPase-activating protein 1
-
?
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
-
Homo sapiens SUMO-3 + Ran GTPase-activating protein 1
-
?
SUMO-1 precursor + H2O 50% of SUMO-1 precursor is hydrolyzed after 70 min Homo sapiens SUMO-1 + His-Ser-Thr-Val
-
?
SUMO-2 precursor + H2O 50% of SUMO-2 precursor is hydrolyzed after 15 min Homo sapiens SUMO-2 + Val-Tyr
-
?
SUMO-3 precursor + H2O 50% of SUMO-1 precursor is hydrolyzed after 160 min Homo sapiens SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
?