Literature summary for 3.4.22.B71 extracted from

Kang, X.; Qi, Y.; Zuo, Y.; Wang, Q.; Zou, Y.; Schwartz, R.J.; Cheng, J.; Yeh, E.T.
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development (2010), Mol. Cell, 38, 191-201.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
SUMO-Pc2/CBX4 conjugate + H2O	Mus musculus	Pc2/CBX4 is a polycomb repressive complex 1 (PRC1) subunit. SENP2 specifically controls Pc2/CBX4 contained PRC1 activity through regulation of the SUMOylation status of Pc2/CBX4, which facilitates its binding to H3K27me3 in mammalian cells to mediate transcriptional repression	SUMO + Pc2/CBX4	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q91ZX6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMO-Pc2/CBX4 conjugate + H2O	Pc2/CBX4 is a polycomb repressive complex 1 (PRC1) subunit. SENP2 specifically controls Pc2/CBX4 contained PRC1 activity through regulation of the SUMOylation status of Pc2/CBX4, which facilitates its binding to H3K27me3 in mammalian cells to mediate transcriptional repression	Mus musculus	SUMO + Pc2/CBX4	-	?
SUMO-Pc2/CBX4 conjugate + H2O	Pc2/CBX4 is a polycomb repressive complex 1 (PRC1) subunit	Mus musculus	SUMO + Pc2/CBX4	-	?

General Information

General Information	Comment	Organism
malfunction	in SENP2 null embryo, SUMOylated Pc2/CBX4 accumulates and Pc2/CBX4 occupancy on the promoters of PcG target genes is markedly increased, leading to repression of Gata4 and Gata6 transcription	Mus musculus
physiological function	SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. SENP2 specifically controls Pc2/CBX4 contained PRC1 activity through regulation of the SUMOylation status of Pc2/CBX4, which facilitates its binding to H3K27me3 in mammalian cells to mediate transcriptional repression	Mus musculus

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Release 2023.1 (January 2023)