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Literature summary for 3.4.22.B71 extracted from

  • Chung, S.S.; Ahn, B.Y.; Kim, M.; Choi, H.H.; Park, H.S.; Kang, S.; Park, S.G.; Kim, Y.B.; Cho, Y.M.; Lee, H.K.; Chung, C.H.; Park, K.S.
    Control of adipogenesis by the SUMO-specific protease SENP2 (2010), Mol. Cell. Biol., 30, 2135-2146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B71

Protein Variants

Protein Variants Comment Organism
C548S catalytically inactive mutant Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SUMO-C/EBPbeta + H2O Mus musculus sumoylation causes destabilization of the C/EBPbeta protein and that this process can be reversed by SENP2 SUMO + C/EBPbeta
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Organism

Organism UniProt Comment Textmining
Mus musculus Q91ZX6
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SUMO-C/EBPbeta + H2O
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 Mus musculus SUMO + C/EBPbeta
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SUMO-C/EBPbeta + H2O sumoylation causes destabilization of the C/EBPbeta protein and that this process can be reversed by SENP2 Mus musculus SUMO + C/EBPbeta
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Expression

Organism Comment Expression
Mus musculus SENP2 expression is markedly increased upon the induction of adipocyte differentiation, and this increase is dependent on protein kinase A activation. Elevated cAMP level induces SENP2 expression through cyclic AMP response element-binding protein (CREB) binding to a functional cis-acting cAMP response element (CRE) in the SENP2 promoter up

General Information

General Information Comment Organism
malfunction knockdown of SENP2 leads to a strong attenuation of adipogenesis with a marked decrease in PPARgamma and C/EBPalpha mRNA levels. Knockdown of SENP2 also causes a marked reduction in the level of C/EBPbeta protein but not in that of C/EBPbeta mRNA Mus musculus
physiological function SENP2 plays a critical role in the control of adipogenesis by desumoylation and stabilization of C/EBPbeta and in turn by promoting the expression of its downstream effectors, such as PPARgamma and C/EBPalpha Mus musculus