Literature summary for 3.4.22.B71 extracted from

Mikolajczyk, J.; Drag, M.; Bekes, M.; Cao, J.T.; Ronai, Z.; Salvesen, G.S.
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs (2007), J. Biol. Chem., 282, 26217-26224.

Search for more literature for 3.4.22.B71

Activating Compound

Activating Compound	Comment	Organism	Structure
SUMO	SUMO domain enhances catalysis of SENP2, substrate induced activation	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression of catalytic domains of SENP2 in Escherichia coli BL21 (DE3) as N-terminal His-tagged proteins	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
catalytic domains of SENP2 expressed in Escherichia coli BL21 (DE3) as N-terminal His-tagged proteins	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	brain	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-QTGG-7-amino-4-trifluoromethylcoumarin + H2O	-	Homo sapiens	acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin	-	?
SUMO-1 precursor + H2O	very low isopeptidase activity with SUMO-1. SENP2 exhibits substantially higher isopeptidase than endopeptidase activity	Homo sapiens	SUMO-1 + His-Ser-Thr-Val	-	?
SUMO-2 precursor + H2O	SENP2 exhibits substantially higher isopeptidase than endopeptidase activity	Homo sapiens	SUMO-2 + Val-Tyr	-	?
SUMO-3 precursor + H2O	SENP2 exhibits substantially higher isopeptidase than endopeptidase activity	Homo sapiens	SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe	-	?
SUMO-Ran GTPase-activating protein 1 conjugate + H2O	SENP2 exhibits substantially higher isopeptidase than endopeptidase activity	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
SENP2	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8.5	-	-	Homo sapiens

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Release 2023.1 (January 2023)