Literature summary for 3.4.22.B69 extracted from

Micale, N.; Cinellu, M.A.; Maiore, L.; Sannella, A.R.; Severini, C.; Schirmeister, T.; Gabbiani, C.; Messori, L.
Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro (2011), J. Inorg. Biochem., 105, 1576-1579.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)(1,3,5-triaza-7-phosphatricyclo[3.3.1.13,7]decane-kappaP)gold	24% inhibition at 0.02 mM	Plasmodium falciparum
auranofin	30% inhibition at 0.02 mM	Plasmodium falciparum
chloro[N-[1-(hydroxy-kappaO)-3-methylbutan-2-yl]pyridine-2-carboxamidato(2-)-kappa2N1,N2]aurate(2-)	43% inhibition at 0.02 mM	Plasmodium falciparum
cisplatin	43% inhibition at 0.02 mM	Plasmodium falciparum
dichloro[3-(propan-2-yl)-2-(pyridin-2-yl-kappaN)-4,5-dihydro-1,3-oxazol-3-ium-kappaN]aurate(1-) hexafluorophosphate	59% inhibition at 0.02 mM	Plasmodium falciparum
potassium bis(1,1-dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)aurate(1-)	66% inhibition at 0.02 mM	Plasmodium falciparum
[3-benzyl-2-(pyridin-2-yl-kappaN)-4,5-dihydro-1,3-oxazol-3-ium-kappaN](dichloro)aurate(1-) hexafluorophosphate	54% inhibition at 0.02 mM	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Hemoglobin + H2O	Plasmodium falciparum	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Cbz-Phe-Arg-7-amido-4-methylcoumarin + H2O	-	Plasmodium falciparum	Cbz-Phe-Arg + 7-amino-4-methylcoumarin	-	?
Hemoglobin + H2O	-	Plasmodium falciparum	?	-	?

Synonyms

Synonyms	Comment	Organism
Fp2	-	Plasmodium falciparum

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Release 2023.1 (January 2023)