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Literature summary for 3.4.22.B66 extracted from

  • Liu, H.; Wang, Z.; Nowicki, M.J.
    Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice (2014), World J. Gastroenterol., 20, 18189-18198.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B66

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum procaspase-12 is predominantly located on the cytoplasmic side of the endoplasmic reticulum Mus musculus 5783
-
microsome
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36000
-
 x * 36000, active enzyme, SDS-PAGE Mus musculus
55000
-
 x * 55000, proenzyme, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O08736
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Subunits

Subunits Comment Organism
? x * 36000, active enzyme, SDS-PAGE Mus musculus
? x * 55000, proenzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
Casp12
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus activation of caspase-12 is detected in the liver at 12 and 24 h after carbon tetrachloride treatment up

General Information

General Information Comment Organism
malfunction carbon tetrachloride-induced apoptosis and liver damage is markedly reduced in caspase-12-deficient mice Mus musculus
physiological function caspase-12 plays a pivotal role in carbon tetrachloride-induced hepatic apoptosis through the activation of the downstream effector caspase-3 directly and/or indirectly via capase-9 activation Mus musculus