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Literature summary for 3.4.22.B66 extracted from

  • Li, L.; Cao, Z.; Jia, P.; Wang, Z.
    Calcium signals and caspase-12 participated in paraoxon-induced apoptosis in EL4 cells (2010), Toxicol. In Vitro, 24, 728-736.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
EL-4 cell
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Mus musculus
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Expression

Organism Comment Expression
Mus musculus O,O-diethyl-O-4-nitrophenylphosphate up-regulates caspase-12 expression in a dose-dependent manner, and pre-treatment with EGTA, heparin or procaine significantly inhibits O,O-diethyl-O-4-nitrophenylphosphate-induced increase of caspase-12 expression. During the application of 5 nM POX for 0-8 h, caspase-12 expression increases significantly and continuously, and reaches the peak after 8 h treatment. However, caspase-12 expression after treatment with 5 nM POX for 16 h is similar to the control up

General Information

General Information Comment Organism
physiological function caspase-12 is an important upstream messenger in POX-induced apoptosis in EL-4 cells Mus musculus