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Literature summary for 3.4.22.B60 extracted from

  • Robinson, M.W.; Dalton, J.P.; Donnelly, S.
    Helminth pathogen cathepsin proteases (2008), Trends Biochem. Sci., 33, 601-608.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Fasciola hepatica Q24940
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O FhCL2 cleaves substrates with a bulky proline in the P2 position as the native collagen, which contains a repeat motif of Gly-Pro-Xaa (in which Xaa is any amino acid). By contrast these substrates are poorly cleaved by FhCL1 and not at all by human cathepsin L Fasciola hepatica ?
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Synonyms

Synonyms Comment Organism
FhCL2
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Fasciola hepatica