Literature summary for 3.4.22.B60 extracted from

Stack, C.M.; Donnelly, S.; Lowther, J.; Xu, W.; Collins, P.R.; Brinen, L.S.; Dalton, J.P.
The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in (2007), J. Biol. Chem., 282, 16532-16543.

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Organism

Organism	UniProt	Comment	Textmining
Fasciola hepatica	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	procathepsin L2 autocatalytically processes and activates to its mature enzyme (FheCL2)	Fasciola hepatica

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
procathepsin L2 + H2O	procathepsin L2 autocatalytically processes and activates to its mature enzyme (FheCL2). FheCL2, which, unlike FheCL1, can readily accept proline in the S2 subsite of its active site, can trans-process the double variant FheproCL1Pro-12/Gly26 by cleavage at the Pro-12-Ser-11-/-His-10 sequence	Fasciola hepatica	?	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin L2 protease	-	Fasciola hepatica
FhCL2	-	Fasciola hepatica

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Release 2023.1 (January 2023)