Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA074 | specific inhibition of CPC | Leishmania amazonensis | |
CA074 | specific inhibition of CPC | Leishmania major | |
CA074 | specific inhibition of CPC | Leishmania mexicana | |
cystatin | protects against Leishmania infection in vivo | Leishmania amazonensis | |
cystatin | protects against Leishmania infection in vivo | Leishmania mexicana | |
Leishmania cysteine peptidase inhibitor 1 | i.e. ICP, inhibitor of CPs from family C1 clan A | Leishmania amazonensis | |
Leishmania cysteine peptidase inhibitor 1 | i.e. ICP, inhibitor of CPs from family C1 clan A | Leishmania major | |
Leishmania cysteine peptidase inhibitor 1 | i.e. ICP, inhibitor of CPs from family C1 clan A | Leishmania mexicana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Leishmania major | 5764 | - |
vacuole | - |
Leishmania mexicana | 5773 | - |
vacuole | - |
Leishmania amazonensis | 5773 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Leishmania amazonensis | the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole | ? | - |
? | |
additional information | Leishmania major | the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection | ? | - |
? | |
additional information | Leishmania mexicana | the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection, the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania amazonensis | - |
- |
- |
Leishmania major | - |
gene CPC | - |
Leishmania mexicana | - |
gene CPC | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | expression in virulence | Leishmania mexicana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole | Leishmania amazonensis | ? | - |
? | |
additional information | the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection | Leishmania major | ? | - |
? | |
additional information | the enzyme might be involved in activation of TGF-beta, a suppressive cytokine in Leishmania infection, the enzyme is involved in the inhibition of antigen presentation by degrading MHC class II molecules in the parasiophorus vacuole | Leishmania mexicana | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CPC | - |
Leishmania mexicana |
CPC | - |
Leishmania amazonensis |
CPC | - |
Leishmania major |
More | the enzyme belongs to the cysteine protease family C1 clan CA | Leishmania mexicana |
More | the enzyme belongs to the cysteine protease family C1 clan CA | Leishmania amazonensis |
More | the enzyme belongs to the cysteine protease family C1 clan CA | Leishmania major |