Literature summary for 3.4.22.B6 extracted from

Selzer, P.M.; Chen, X.; Chan, V.J.; Cheng, M.; Kenyon, G.L.; Kuntz, I.D.; Sakanari, J.A.; Cohen, F.E.; McKerrow, J.H.
Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors (1997), Exp. Parasitol., 87, 212-221.

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Inhibitors

Inhibitors	Comment	Organism	Structure
PS28	IC50: 0.01 mM	Leishmania major
ZLIII115A	IC50: 0.01 mM	Leishmania major
ZLIII33A	IC50: 0.0005	Leishmania major
ZLIII43A	IC50: 0.002 mM	Leishmania major

Organism

Organism	UniProt	Comment	Textmining
Leishmania major	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
promastigote	-	Leishmania major	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is not able to cleave synthetic substrates having an Arg in position P2	Leishmania major	?	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0005	-	IC50: 0.0005 mM	Leishmania major	ZLIII33A
0.002	-	IC50: 0.002 mM	Leishmania major	ZLIII43A
0.01	-	IC50: 0.01 mM	Leishmania major	PS28
0.01	-	IC50: 0.01 mM	Leishmania major	ZLIII115A

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Release 2023.1 (January 2023)