Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells | porcine epidemic diarrhea virus |
Protein Variants | Comment | Organism |
---|---|---|
C1729A | the mutant shows reduced interferon antagonistic activity compared to that of the wild type enzyme | porcine epidemic diarrhea virus |
D1901A | the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme | porcine epidemic diarrhea virus |
H1888A | the mutant almost completely loses interferon antagonistic activity compared to that of the wild type enzyme | porcine epidemic diarrhea virus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquitin + H2O | porcine epidemic diarrhea virus | the enzyme processes both K-48 and K-63 linked polyubiquitin chains | ? | - |
? | |
ubiquitinated RIG-I + H2O | porcine epidemic diarrhea virus | - |
deubiquitinated RIG-I + ubiquitin | - |
? | |
ubiquitinated STING + H2O | porcine epidemic diarrhea virus | - |
deubiquitinated STING + ubiquitin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
porcine epidemic diarrhea virus | P0C6Y4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquitin + H2O | the enzyme processes both K-48 and K-63 linked polyubiquitin chains | porcine epidemic diarrhea virus | ? | - |
? | |
ubiquitinated RIG-I + H2O | - |
porcine epidemic diarrhea virus | deubiquitinated RIG-I + ubiquitin | - |
? | |
ubiquitinated STING + H2O | - |
porcine epidemic diarrhea virus | deubiquitinated STING + ubiquitin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLP2 | - |
porcine epidemic diarrhea virus |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme strongly inhibits RIG-Iand STING-activated interferon expression. Papain-like protease 2 acts as a viral deubiquitinase to interfere with the RIG-I- and STING-mediated signalling pathway | porcine epidemic diarrhea virus |