Cloned (Comment) | Organism |
---|---|
expressed in HEK-293T cells | Murine hepatitis virus |
Protein Variants | Comment | Organism |
---|---|---|
C106A | inactive | Murine hepatitis virus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Murine hepatitis virus | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Murine hepatitis virus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
papain-like protease domain 2 | a catalytic domain of the nonstructural protein 3 of mouse hepatitis virus A59 | Murine hepatitis virus |
PLP2 | - |
Murine hepatitis virus |
General Information | Comment | Organism |
---|---|---|
physiological function | papain-like protease domain 2 (PLP2) deubiquitinates TANK-binding kinase-1 (TBK1) and reduces its kinase activity, hence inhibits interferon-beta reporter activity and prevents interferon regulatory factor 3 (IRF3) nuclear translocation. The presence of PLP2 stabilizes the hypo-phosphorylated IRF3-TBK1 complex in a dose-dependent manner in the cytoplasm | Murine hepatitis virus |