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Literature summary for 3.4.22.B50 extracted from

  • Chaudhuri, R.; Tang, S.; Zhao, G.; Lu, H.; Case, D.A.; Johnson, M.E.
    Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications (2011), J. Mol. Biol., 414, 272-288.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.B50

Application

Application Comment Organism
medicine the enzyme is a potential targets for antiviral drug development Human coronavirus NL63

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
FTKLAGGKISFS + H2O Human coronavirus NL63
-
 FTKLAG + GKISFS
-
 ?
ubiquitin + H2O Human coronavirus NL63 the enzyme cleaves the LRGG tail of ubiquitin ?
-
 ?
VAKQGAGFKRTY + H2O Human coronavirus NL63
-
 VAKQGA + GFKRTY
-
 ?

Organism

Organism UniProt Comment Textmining
Human coronavirus NL63
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FTKLAGGKISFS + H2O
-
 Human coronavirus NL63 FTKLAG + GKISFS
-
 ?
ubiquitin + H2O the enzyme cleaves the LRGG tail of ubiquitin Human coronavirus NL63 ?
-
 ?
VAKQGAGFKRTY + H2O
-
 Human coronavirus NL63 VAKQGA + GFKRTY
-
 ?

Synonyms

Synonyms Comment Organism
PLP2
-
 Human coronavirus NL63