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Literature summary for 3.4.22.B50 extracted from

  • Barretto, N.; Jukneliene, D.; Ratia, K.; Chen, Z.; Mesecar, A.D.; Baker, S.C.
    The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity (2005), J. Virol., 79, 15189-15198.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli XL-1 Blue and HeLa-MHV receptor cells Alphacoronavirus

Protein Variants

Protein Variants Comment Organism
C1651A purified SARS-CoV PLpro protein containing an alanine substitution at putative catalytic residues Alphacoronavirus
C1732A encodes a substitution of a cysteine residue, predicted to be critical for zinc binding Alphacoronavirus
D1826A purified SARS-CoV PLpro protein containing an alanine substitution at putative catalytic residues Alphacoronavirus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
-
Alphacoronavirus

Organism

Organism UniProt Comment Textmining
Alphacoronavirus
-
SARS-CoV
-
Alphacoronavirus SARS-CoV
-
SARS-CoV
-

Purification (Commentary)

Purification (Comment) Organism
purified to homogeneity by hydrophobic interaction and anion exchange chromatography Alphacoronavirus

Storage Stability

Storage Stability Organism
-80°C, Tris buffer, pH 7.5, 20% glycerol Alphacoronavirus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E-EDANS)RELNGGAPI(K-DABCYL)S + H2O
-
Alphacoronavirus ?
-
?
(E-EDANS)RELNGGAPI(K-DABCYL)S + H2O
-
Alphacoronavirus SARS-CoV ?
-
?
diubiquitin + H2O
-
Alphacoronavirus ?
-
?
diubiquitin + H2O
-
Alphacoronavirus SARS-CoV ?
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
-
Alphacoronavirus ?
-
?
ubiquitin-7-amido-4-methylcoumarin + H2O
-
Alphacoronavirus SARS-CoV ?
-
?

Synonyms

Synonyms Comment Organism
papain-like proteinase
-
Alphacoronavirus
PLpro
-
Alphacoronavirus