Cloned (Comment) | Organism |
---|---|
- |
Murine coronavirus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | not sensitive to cysteine protease inhibitor E64d | Murine coronavirus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Murine coronavirus | the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein | ? | - |
? | |
replicase polyprotein + H2O | Murine coronavirus | PLP2 cleaves a substrate encoding the first predicted membrane-spanning domain, MP1, of the replicase polyprotein. Processing the replicase polyprotein at this site generates the p150 replicase intermediate that is likely critical for embedding the replicase complex into cellular membranes. The enzyme acts efficiently in trans | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Murine coronavirus | - |
i.e. mouse hepatitis virus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cys1715 is a catalytic residue of PLP2 | Murine coronavirus | ? | - |
? | |
additional information | the enzyme is one of three distinct viral proteases (PLP1, PLP2 and 3CLpro) involved in processing of the replicase polyprotein | Murine coronavirus | ? | - |
? | |
replicase polyprotein + H2O | PLP2 cleaves a substrate encoding the first predicted membrane-spanning domain, MP1, of the replicase polyprotein. Processing the replicase polyprotein at this site generates the p150 replicase intermediate that is likely critical for embedding the replicase complex into cellular membranes. The enzyme acts efficiently in trans | Murine coronavirus | ? | - |
? |