Any feedback?
Literature summary for 3.4.22.B5 extracted from
- Leishmania CPA, CPB and CPC cysteine proteases (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press, 2, 1166-1169.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Leishmanial cysteine protease is implicated in modulation of the host immune system to favor parasite survival and proliferation, the enzyme has vaccine potential and is involved in effecting a cell death process in the parasite | Leishmania mexicana |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Leishmania mexicana |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| megasome | - |
Leishmania mexicana | 43246 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania mexicana | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| gel filtration and anion exchange chromatography | Leishmania mexicana |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| amastigote | isolated from infected mice, expression of CPB3-CPB18 | Leishmania mexicana | - |
| promastigote | from sandfly, expression of CPB1-CPB2 | Leishmania mexicana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | all CPB isoenzymes hydrolyze substrates containing a Pro-Phe-Arg moiety well but the enzymes differ in their activities towards Leu-Val-Tyr, Phe-Val-Arg or Leu-Tyr containing substrates as well | Leishmania mexicana | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CPB1 | - |
Leishmania mexicana |
| CPB10 | - |
Leishmania mexicana |
| CPB11 | - |
Leishmania mexicana |
| CPB12 | - |
Leishmania mexicana |
| CPB13 | - |
Leishmania mexicana |
| CPB14 | - |
Leishmania mexicana |
| CPB15 | - |
Leishmania mexicana |
| CPB16 | - |
Leishmania mexicana |
| CPB17 | - |
Leishmania mexicana |
| CPB18 | - |
Leishmania mexicana |
| CPB19 | - |
Leishmania mexicana |
| CPB2 | - |
Leishmania mexicana |
| CPB3 | - |
Leishmania mexicana |
| CPB4 | - |
Leishmania mexicana |
| CPB5 | - |
Leishmania mexicana |
| CPB6 | - |
Leishmania mexicana |
| CPB7 | - |
Leishmania mexicana |
| CPB8 | - |
Leishmania mexicana |
| CPB9 | - |
Leishmania mexicana |
| type I cysteine protease | - |
Leishmania mexicana |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
