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Literature summary for 3.4.22.B5 extracted from

  • Alves, L.C.; St.Hilaire, P.M.; Meldal, M.; Sanderson, S.J.; Mottram, J.C.; Coombs, G.H.; Juliano, L.; Juliano, M.A.
    Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicana (2001), Mol. Biochem. Parasitol., 114, 81-88.
    View publication on PubMed
Search for more literature for 3.4.22.B5

Inhibitors

Inhibitors Comment Organism Structure
EAEFAARYLNGAAYF-NH2
-
 Leishmania mexicana
FAARYLNGA
-
 Leishmania mexicana
FAARYLNGA-NH2
-
 Leishmania mexicana
FAARYLNGAQ-[N-(2,4-dinitrophenyl)]-ethylenediamine
-
 Leishmania mexicana
ITKFFDLSEAEFAA-NH2
-
 Leishmania mexicana
KLSKYLSK-NH2
-
 Leishmania mexicana
LKLLRKM-NH2
-
 Leishmania mexicana
NPHAQFGITKFFDL-NH2
-
 Leishmania mexicana
o-aminobenzoyl-FAARYLNGA-NH2
-
 Leishmania mexicana
o-aminobenzoyl-FAARYLNGAQ-[N-(2,4-dinitrophenyl)]-ethylenediamine
-
 Leishmania mexicana
o-aminobenzoyl-KLSKYLSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine)
-
 Leishmania mexicana
o-aminobenzoyl-KLSKYLSKQ-[N-(2,4-dinitrophenyl)-ethylenediamine]
-
 Leishmania mexicana
o-aminobenzoyl-LKLLRKMQ-(N-[2,4-dinitrophenyl]-ethylenediamine)
-
 Leishmania mexicana
o-aminobenzoyl-RIIRIKRQ-(N-[2,4-dinitrophenyl]-ethylenediamine)
-
 Leishmania mexicana
o-aminobenzoyl-YRFFRNRFQ-(N-[2,4-dinitrophenyl]-ethylenediamine)
-
 Leishmania mexicana
RYLNGAAYFAAAKR-NH2
-
 Leishmania mexicana
SEAEFAARYLNGAA-NH2
-
 Leishmania mexicana
YFAAAKRHAAQHYR-NH2
-
 Leishmania mexicana

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00017
-
 o-aminobenzoyl-KLFNPKFQ-(N-(2,4-dinitrophenyl)-ethylenediamine) pH 5.5, 37°C Leishmania mexicana
0.00044
-
 o-aminobenzoyl-ANHFLCTQ-(N-(2,4-dinitrophenyl)-ethylenediamine) pH 5.5, 37°C Leishmania mexicana

Organism

Organism UniProt Comment Textmining
Leishmania mexicana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NPHAQFGITKFFDK-NH2 + H2O
-
 Leishmania mexicana NPHAQFGIT + KFFDK-NH2
-
 ?
o-aminobenzoyl-ANHFLCTQ-(N-(2,4-dinitrophenyl)-ethylenediamine) + H2O
-
 Leishmania mexicana o-aminobenzoyl-ANHFL + CTQ-(N-(2,4-dinitrophenyl)-ethylenediamine)
-
 ?
o-aminobenzoyl-KLFNPKFQ-(N-(2,4-dinitrophenyl)-ethylenediamine) + H2O
-
 Leishmania mexicana o-aminobenzoyl-KLF + NPKFQ-(N-(2,4-dinitrophenyl)-ethylenediamine)
-
 ?
o-aminobenzoyl-KLSKYLSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine) + H2O slow hydrolysis at D-/-K and L-/-S Leishmania mexicana o-aminobenzoyl-KLS + KYLSKQ-(N-(2,4-dinitrophenyl)-ethylenediamine)
-
 ?
RYLNGAAYFAAAKR-NH2 + H2O hydrolysis at RYLNGAAYF-/-A-/-AAKR-NH2 Leishmania mexicana ?
-
 ?
YFAAAKRHAAQHYR-NH2 + H2O
-
 Leishmania mexicana YFA + AAKRHAAQHYR-NH2
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.7
-
 o-aminobenzoyl-KLFNPKFQ-(N-(2,4-dinitrophenyl)-ethylenediamine) pH 5.5, 37°C Leishmania mexicana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000007
-
 o-aminobenzoyl-KLSKYLSKQ-[N-(2,4-dinitrophenyl)-ethylenediamine] pH 5.5, 37°C Leishmania mexicana
0.00003
-
 o-aminobenzoyl-FAARYLNGAQ-[N-(2,4-dinitrophenyl)-ethylenediamine] pH 5.5, 37°C Leishmania mexicana
0.00006
-
 o-aminobenzoyl-FAARYLNGA-NH2 pH 5.5, 37°C Leishmania mexicana
0.0001
-
 RYLNGAAYFAAAKR-NH2 pH 5.5, 37°C Leishmania mexicana
0.0002
-
 NPHAQFGITKFFDL-NH2 pH 5.5, 37°C Leishmania mexicana
0.00045
-
 FAARYLNGAQ-[N-(2,4-dinitrophenyl)-ethylenediamine] pH 5.5, 37°C Leishmania mexicana
0.00055
-
 YFAAAKRHAAQHYR-NH2 pH 5.5, 37°C Leishmania mexicana
0.00081
-
 EAEFAARYLNGAAYF-NH2 pH 5.5, 37°C Leishmania mexicana
0.0012
-
 SEAEFAARYLNGAA-NH2 pH 5.5, 37°C Leishmania mexicana
0.0017
-
 ITKFFDLSEAEFAA-NH2 pH 5.5, 37°C Leishmania mexicana
0.004
-
 FAARYLNGA pH 5.5, 37°C Leishmania mexicana
0.0041
-
 FAARYLNGA-NH2 pH 5.5, 37°C Leishmania mexicana