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Literature summary for 3.4.22.B49 extracted from

  • Dalton, J.P.; Neill, S.O.; Stack, C.; Collins, P.; Walshe, A.; et al.
    Fasciola hepatica cathepsin L-like protease: biology, function, and potential in the development of the first generation liver fluke vaccines (2003), Int. J. Parasitol., 33, 1173-1181.
    View publication on PubMed
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Application

Application Comment Organism
medicine potential in the development of first generation liver fluke vaccines. Vaccine trials in both sheep and cattle with purified native FheCL1 and FheCL2 show that the enzymes can induce protection, ranging from 33-79%, to experimental challenge with metacercariae of Fasciola hepatica, and very potent anti-embryonation/hatch rate effects that would block parasite transmission Fasciola hepatica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Fasciola hepatica the enzyme facilitates the penetration of the parasite though the tissue of its host, and also participates in functions such as feeding and immune evasion ?
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Organism

Organism UniProt Comment Textmining
Fasciola hepatica
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme facilitates the penetration of the parasite though the tissue of its host, and also participates in functions such as feeding and immune evasion Fasciola hepatica ?
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 ?