Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q11002 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blastoderm | - |
Drosophila melanogaster | - |
embryo | - |
Drosophila melanogaster | - |
Synonyms | Comment | Organism |
---|---|---|
calpain-A | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | a significant percentage of embryos from hypomorphic or knockdown calpain A mothers are lethal and do not complete embryogenesis. Lethality is increased as maternal calpain A function is reduced. Impaired Calpain A function results in loss of mitotic synchrony and ultimately halted embryonic development. Calpain A is required for the metaphase-to-anaphase transition, loss leads to presence of defective microtubules and chromosomal architecture at the mitotic spindle during metaphase and anaphase and perturbed levels of Cyclin B | Drosophila melanogaster |