Literature summary for 3.4.22.B26 extracted from

Tonami, K.; Kurihara, Y.; Arima, S.; Nishiyama, K.; Uchijima, Y.; Asano, T.; Sorimachi, H.; Kurihara, H.
Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1 (2011), J. Cell Sci., 124, 1214-1223.

Search for more literature for 3.4.22.B26

Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-L-leucyl-L-leucinal	-	Mus musculus
calpeptin	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
NIH-3T3 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
calpain-6	-	Mus musculus
CAPN6	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	calpain-6 mRNA and CAPN6 protein levels are down-regulated by 10% fetal calf serum	down

General Information

General Information	Comment	Organism
malfunction	knockdown of calpain-6 in NIH-3T3 cells results in Rac1 activation, which promotes cell migration, spreading and lamellipodial protrusion. Upon knockdown of calpain-6, GEF-H1 translocates from microtubules to the lamellipodial region and to interact with Rac1. RhoA activity is decreased upon knockdown of calpain-6	Mus musculus
physiological function	calpain-6 is a microtubule-stabilizing protein that regulates Rac1 activity and cell motility through interaction with the Rho guanine-nucleotide-exchange factor GEF-H1. Calpain-6 is involved in the regulation of the organization of cortical actin and subsequent changes in cell motility and morphology, independent of the proteolytic activity of calpains	Mus musculus

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Release 2023.1 (January 2023)