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Literature summary for 3.4.22.B19 extracted from

  • Zheng, Y.; Lilo, S.; Mena, P.; Bliska, J.B.
    YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense (2012), PLoS ONE, 7, e36019.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C172A site-directed mutagenesis, catalytically inactive enzyme Yersinia pestis

Organism

Organism UniProt Comment Textmining
Yersinia pestis
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Yersinia pestis KIM5
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Synonyms

Synonyms Comment Organism
Yersinia outer protein J
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Yersinia pestis
YopJ
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Yersinia pestis
YopJKIM
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Yersinia pestis

General Information

General Information Comment Organism
evolution different Yersinia strains exhibit a range of cytotoxic activities on macrophages and this heterogeneity has been linked to allelic variation of genes encoding YopJ/YopP proteins, overview Yersinia pestis
metabolism mechanism of enzme YopJKIM-induced cell death, caspase-1 activation, and IL-1beta secretion in primary murine macrophages, overview. Caspase-3/7 activity is low and the caspase-3 substrate poly (ADP-ribose) polymerase is not cleaved in Yersinia pestis KIM5-infected macrophages. Enzyme YopJKIM-mediated cell death and caspase-1 activation occur independent of mitochondrial-directed apoptosis, Apoptotic signaling through caspase-8 and mitochondria is dispensable for KIM5-induced macrophage death, RIP1 and reactive oxygen species are not required for YopJKIM-induced cell death or IL-beta secretion Yersinia pestis
physiological function Yersinia outer protein J is a type III secretion system effector of pathogenic Yersinia, i.e. Yersinia pestis, Yersinia enterocolitica and Yersinia pseudotuberculosis, that is secreted into host cells. YopJ inhibits survival response pathways in macrophages, causing cell death. Allelic variation of enzyme YopJ is responsible for differential cytotoxicity in Yersinia strains. Enzme YopJKIM-induced macrophage death is associated with caspase-1 activation and interleukin-1beta secretion Yersinia pestis