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Literature summary for 3.4.22.B19 extracted from

  • Orth, K.; Xu, Z.; Mudgett, M.B.; Bao, Z.Q.; Palmer, L.E.; Bliska, J.B.; Mangel, W.F.; Staskawicz, B.; Dixon, J.E.
    Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease (2000), Science, 290, 1594-1597.
    View publication on PubMed
Search for more literature for 3.4.22.B19

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
-
 Yersinia sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Yersinia sp. the virulence factor YopJ cleaves reversibly post-translational modification in form of ubiquitin or a ubiquitin-like protein. It inhibits the host immune response and induces apoptosis by blocking multiple signaling pathways, including the MAPK and NfkappaB pathways in the infected cell ?
-
 ?

Organism

Organism UniProt Comment Textmining
Yersinia sp.
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the virulence factor YopJ cleaves reversibly post-translational modification in form of ubiquitin or a ubiquitin-like protein. It inhibits the host immune response and induces apoptosis by blocking multiple signaling pathways, including the MAPK and NfkappaB pathways in the infected cell Yersinia sp. ?
-
 ?
additional information YopJ is delivered into the target host cytosol via a type III secretion system. YopJ blocks activation of the superfamily of MAPK kinases, including MKKs and IKKbeta. The inhibition results in the inability of the cell to produce cytokines and antiapoptotic machinery Yersinia sp. ?
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 ?