Literature summary for 3.4.22.B14 extracted from

Kanjanahaluethai, A.; Baker, S.C.
Coronavirus papain-like endopeptidases (2004), Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. )Academic Press, 2, 1265-1269.

No PubMed abstract available

Search for more literature for 3.4.22.B14

Cloned(Commentary)

Cloned (Comment)	Organism
-	Murine hepatitis virus

Inhibitors

Inhibitors	Comment	Organism	Structure
E-64d	membrane-permeable do the irreversible cysteine proteinase inhibitor E-64 blocks cleavage of p65 in vivo	Murine hepatitis virus
leupeptin	blocks the ability of PLP1 to cleave p28 in vitro but not in vivo due to permeability and toxicity issues	Murine hepatitis virus
ZnCl2	blocks the ability of PLP1 to cleave p28 in vitro but not in vivo due to permeability and toxicity issues	Murine hepatitis virus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
28000	-	-	Murine hepatitis virus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
p28	Murine hepatitis virus	-	?	-	?
p65	Murine hepatitis virus	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Murine hepatitis virus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Murine hepatitis virus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
p28	-	Murine hepatitis virus	?	-	?
p65	-	Murine hepatitis virus	?	-	?

Synonyms

Synonyms	Comment	Organism
first papain-like cysteine proteinase	-	Murine hepatitis virus
PLP1	-	Murine hepatitis virus

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Release 2023.1 (January 2023)