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Literature summary for 3.4.22.71 extracted from

  • Zong, Y.; Mazmanian, S.K.; Schneewind, O.; Narayana, S.V.L.
    The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall (2004), Structure, 12, 105-112.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor diffusion method. Crystal structure of SrtB-DELTA-N30 in complex with two active site inhibitors E64 and MTSET, and with the cell wall substrate analog tripleglycine Staphylococcus aureus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IsdC + H2O Staphylococcus aureus the enzyme cleaves the C-terminal sorting signal of IsdC at the NPQTN motif and rethers the polypeptide to the pentaglycine cell wall cross-bridge. During catalysis, the active site cysteine of sortase and the cleaved substrate form an acyl intermediate, which is then resolved by the amino group of pentaglycine cross-bridges ?
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Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
IsdC + H2O the enzyme cleaves the C-terminal sorting signal of IsdC at the NPQTN motif and rethers the polypeptide to the pentaglycine cell wall cross-bridge. During catalysis, the active site cysteine of sortase and the cleaved substrate form an acyl intermediate, which is then resolved by the amino group of pentaglycine cross-bridges Staphylococcus aureus ?
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 ?